BacterioScan allows for an alternative method of screening with satisfactory sensitivity and improved specificity that may facilitate a reduction of unnecessary cultures. Additional studies are required to determine if a concomitant decrease in inappropriate antibiotic use can be realized with the 216Dx technology.

BacterioScan 216Dx is a recently FDA-cleared semiautomated system for qualitative determination of the presence or absence of viable bacteria in urine samples.

American Society for Microbiology, Antimicrobial Agents and Chemotherapy.

The aim of this study was to compare the performance of 216 DX and UA against culture as gold standard.

The objective of this study is to compare a novel UTI detection method (BacterioScan 216Dx UTI System) to urinalysis for screening urine samples for reflex to culture.

Our lab evaluated the 216Dx’s ability to provide rapid antimicrobial susceptibility testing (AST) data using samples deemed positive during the UTI screening protocol.

Delays in appropriate antimicrobial treatment contribute to increased mortality of septic patients. We aimed to develop a methodology for detection of carbapenem resistance in Gram-negative bacteria directly from positive blood cultures (BCs).

This study examines the application of laser scattering for bacterial detection and antimicrobial scattering for bacterial detection and antimicrobial susceptibility testing (AST) directly from urine.

By rapidly identifying urine cultures likely to be positive, NAFLST with Bacterioscan can obviate the plating of every urine sample and reduce empiric antibiotic use while waiting for culture results.

The phenotypic AST methods developed in this study are promising for rapid detection of MRSA and VRE. Further studies are required to investigate and validate these approaches for detecting other important resistance phenotypes. Future studies should also focus on direct testing from clinical specimens.

Laser light-scattering can be a useful method for rapidly profiling clinical urine specimens for UTI positivity/negativity.

Urine culture is often performed in high volume with many negative samples that require 18-24 hours for results. Screening urine samples for organism prior to culture may reduce this volume and provide more timely information.

Faster, but accurate, alternatives are needed. Light scatter technology has been proposed for several years as a rapid screening tool, whereby negative specimens are excluded from culture.

Rapid antimicrobial susceptibility testing (AST) enables clinicians to prescribe targeted therapies more quickly, thereby improving patient care and promoting antibiotic stewardship.

This study evaluates the use of forward laser light scatter (FLLS) to measure bacterial growth for the early determination of antimicrobial susceptibility.

The prevalence of multidrug resistant Gram-negative bacteria is increasing worldwide. Therefore, rapid detection of carbapenem resistance is critical for early initiation of an appropriate antimicrobial treatment.

The described real-time growth-based susceptibility testing approach is promising for rapid detection of vancomycin-resistant enterococci.

Rapid methods to determine antimicrobial susceptibility would assist in the timely distribution of effective treatment or postexposure prophylaxis in the aftermath of the release of bacterial biothreat agents such as Bacillus anthracis, Yersinia pestis, or Burkholderia pseudomallei.

The BacterioScan laser microbial growth monitor is a compact diagnostic instrument that measures the growth of microorganisms in real-time, with a lower limit of detection of 1x104 CFU/ml.

Real-time laser-scattering method using BacterioScanTM216R allows for rapid phenotypic MRSA detection. Optimization of inoculum size, broth, cut-off criteria and other conditions may allow even shorter time to result.